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) 92 (69.2 ) 0.655 28 18 117 79 6 2 (7.1 ) 0 (.0 ) 6 (5.1 ) 5 (6.3 ) 8 (28.6 ) 10 (55.6 ) 27 (23.1 ) 14 (17.7 ) 18 (64.3 ) 8 (44.4 ) 84 (71.8 ) 60 (75.9 ) 0.161 163 18 19 11 11 5 21 6 (3.7 ) 3 (16.7 ) 0 (.0 ) 1 (9.1 ) 0 (.0 ) 1 (20.0 ) 36 (22.1 ) 6 (33.3 ) 7 (36.8 ) 1 (9.1 ) 4 (36.4 ) 1 (20.0 ) 121 (74.2 ) 9 (50.0 ) 12 (63.2 ) 9 (81.8 ) 7 (63.6 ) 3 (60.0 ) 0.077 16
) 92 (69.2 ) 0.655 28 18 117 79 6 2 (7.1 ) 0 (.0 ) 6 (5.1 ) 5 (6.3 ) 8 (28.6 ) 10 (55.6 ) 27 (23.1 ) 14 (17.7 ) 18 (64.3 ) 8 (44.4 ) 84 (71.8 ) 60 (75.9 ) 0.161 163 18 19 11 11 5 21 6 (3.7 ) 3 (16.7 ) 0 (.0 ) 1 (9.1 ) 0 (.0 ) 1 (20.0 ) 36 (22.1 ) 6 (33.3 ) 7 (36.8 ) 1 (9.1 ) 4 (36.4 ) 1 (20.0 ) 121 (74.2 ) 9 (50.0 ) 12 (63.2 ) 9 (81.8 ) 7 (63.6 ) 3 (60.0 ) 0.077 16
The rise of CSC theory, some specific CSC markers were being discovered to identify putative CSCs, and ALDH1 is becoming to act as a CSC marker in the CSC studies of variable tumor types in vitro and in vivo. Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which may be a feature of CSC. Compared to ALDH1(-) EMT cells, only ALDH1(+) EMT cells had
Sion and Negative groups (p < 0.05, Kaplan-Meier). b High expression level of ALDH1 in tumor cells in ovarian carcinomas was significantly associated with high PFS probabilities (p < 0.05, Kaplan-Meier). c The expression level of ALDH1 in the stromal cells in ovarian carcinoma had no significant association with OS probabilities (p > 0.05, Kaplan-Meier). d No statistical association was found bet
Is still the most lethal gynecologic malignancy worldwide. Although most ovarian carcinoma cells are initially sensitive to chemotherapy, there is always a small population cells that always survives and initiates new tumors which causes recurrence [31]. The verification of tumor heterogeneity further enhances the hypothesis of CSCs. Compelling evidence has shown that ovarian carcinomas with enri
Etc. [34, 35]. However, it still remains challenging to identify one single marker or several combined markers to specifically identify all the CSCs in ovarian tumor, and the exact roles of these `stemness' related markers, are still poorly understood due to either a current lack of understanding of the biological functions of the markers, or frequently the lack of information correlating the var
Etc. [34, 35]. However, it still remains challenging to identify one single marker or several combined markers to specifically identify all the CSCs in ovarian tumor, and the exact roles of these `stemness' related markers, are still poorly understood due to either a current lack of understanding of the biological functions of the markers, or frequently the lack of information correlating the var
Sion and Negative groups (p < 0.05, Kaplan-Meier). b High expression level of ALDH1 in tumor cells in ovarian carcinomas was significantly associated with high PFS probabilities (p < 0.05, Kaplan-Meier). c The expression level of ALDH1 in the stromal cells in ovarian carcinoma had no significant association with OS probabilities (p > 0.05, Kaplan-Meier). d No statistical association was found bet