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Nt years [32]. In their study, dual positive cells of ALDH1 and another traditional ovarian CSC marker CD133 were isolated directly from human tumor to initiate tumor in mice, and these cells displayed enhanced angiogenesis and tumorigenicity like other CSCs [32]. Moreover, the patients with CD133(+)/ALDH1(+) tumor cells displayed reduced PFS and OS [32]. Distinct expression levels and patterns of



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