M HIVmediated immune hyperactivation (9). Such beneficial versus detrimental effects of Treg in HIV infection have been a subject of controversy in recent years (30, 32?5). In addition, the fact that Tregs are a subset of CD4+ T cells expressing CXCR4 and CCR5 coreceptors makes these cells susceptible of being infected by HIV, complicating even more the comprehension of the real role of Tregs in H