In [58]). Histone methylation has not been studied as extensively as other histone modifications with respect to PCa, but some promising preliminary data are emerging. Similar to other epigenetic marks, histone methylation has been associated with tumor suppressor and adhesion molecule gene silencAm J Cancer Res 2012;2(6):620-Prostate cancer biomarkersing. Trimethylation of lysine 27 of histone H3