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Active, signalling-competent inflammasome. Higher-order signalosomes were reported for other innate immune signalling pathways (Toll-like receptors, receptor-interacting serine/threonine-protein kinase 2 (RIP2K) and MAVS) and could promote signal amplification and digital all-or-nothing responses48, leading us to hypothesize that ASC oligomerization and filament formation might have a similar func



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